Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4
Our findings reveal that mifepristone impairs trophoblast function by antagonizing PGR and inducing PDCD4, thereby impairing stemness and promoting apoptosis. This mechanistic insight not only advances our understanding of mifepristone's action in RPOC treatment but also suggests broader clinical implications for targeting trophoblast function.
Authors
- Duo Zhang (ORCID: https://orcid.org/0000-0002-0092-9042)
- Qian Zhu (ORCID: https://orcid.org/0000-0001-7062-8221)
- Yan Li (ORCID: https://orcid.org/0000-0002-5938-8519)
- Jian Zhang
- Yamei Li
- Xiaoya Zhao
- Jie Zhou
- Qicheng Lan
- Suming Huang
Institutions
- Shanghai Medical College of Fudan University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai Municipal People's Government (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s13578-025-01508-5
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00