MTAP in small biopsy samples of pancreatic lesions: a potential diagnostic biomarker. Immunohistochemical, fluorescence in situ hybridization and molecular analysis
An immunohistochemical immunohistochemical panel including MTAP and S100P improves diagnostic accuracy in PDAC diagnosis, showing a better sensitivity (75%) and the same specificity compared to single markers. FISH showed an incomplete sensitivity in identifying all cases with HD of CDKN2A, with two cases MTAP negative by IHC and identified as deleted only by molecular study.
Authors
- Ferdinando De Vita (ORCID: https://orcid.org/0000-0002-7654-7470)
- Valeria Masola
- Eduardo Clery
- Giovanni Conzo (ORCID: https://orcid.org/0000-0003-4015-0970)
- Roberto Sirica (ORCID: https://orcid.org/0000-0002-3923-4889)
- Immacolata Cozzolino
- Marco Montella (ORCID: https://orcid.org/0000-0002-8588-7653)
- Federica Zito Marino
- Danilo Porpora
- Giovanni Savarese (ORCID: https://orcid.org/0009-0004-5274-3989)
- Renato Franco
- Stefano Lucà
- Cecilia Salzillo
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Pathologica
- Published
- 2025-12-01
- DOI
- https://doi.org/10.32074/1591-951x-1243
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00