Relation between <i>hOGG1</i> rs1052133 polymorphism with the susceptibility of hepatocellular carcinoma: a meta-analysis

Abstract Objectives Human 8-hydroxy guanine DNA glycosylase (hOGG1) is a DNA repair enzyme associated with hepatocellular carcinoma (HCC). This study aimed to investigate the pooled relationship between hOGG1 rs1052133 polymorphism and HCC susceptibility. Methods Eligible articles were searched from PubMed, EMBASE, China Knowledge Network (CNKI), and WanFang databases. Random or fixed effects models were employed to assess pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the association. Subgroup analysis based on ethnicity and control source was performed to assess the source of heterogeneity. Results High heterogeneity was discovered in five genetic models. Therefore, the pooled association was discovered under the random-effect model. hOGG1 rs1052133 was significantly related to HCC vulnerability under CG + GG vs. CC (OR=1.38, 95 % CI=1.04–1.83), CG vs. CC (OR=1.44, 95 % CI=1.12–1.84) genetic models. Subgroup analysis based on ethnicity indicated that rs1052133 was linked to elevated HCC risk in the Caucasian subgroup under G vs. C (OR=1.76, 95 % CI=1.22–2.56), CG + GG vs. CC (OR=2.72, 95 % CI=1.48–4.99), GG vs. CC (OR=2.51, 95 % CI=1.10–5.72), CG vs. CC (OR=2.66, 95 % CI=1.19–5.96) genetic models. Notably, the ORs were modest when considering the 95 % CIs. The study was largely free of publication bias. Conclusions The hOGG1 rs1052133 was significantly associated with HCC risk, especially in Caucasians.