Sevoflurane attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via the LncRNA FAM201A/miR-488-3p/PTEN axis
Sevo preconditioning protects against H/R injury by downregulating FAM201A, which sponges miR-488-3p to reduce PTEN and activate PI3K/AKT signaling. Targeting this axis may provide potential therapeutic targets for IRI.
Authors
- Qiuxin Li
- Y Chen
- Jinping Li (ORCID: https://orcid.org/0009-0007-5838-6291)
- Chen Yang (ORCID: https://orcid.org/0000-0002-6371-5930)
- Huiling Qin (ORCID: https://orcid.org/0009-0005-5287-0192)
- Yuanzhi Li
- Xibao Shi
Institutions
- Shanghai Jiao Tong University (CN)
- Xiamen University (CN)
- Ruijin Hospital (CN)
- People 's Hospital of Jilin Province (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s12871-025-03545-6
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00