The combination of rosuvastatin and meloxicam enhances the radiotherapy efficacy of MCF7, T-47D, and MDA-MB-231 breast cancer cell lines
The combination of rosuvastatin and meloxicam at specific concentrations increased the radiation sensitivity of MCF-7, T-47D, and MDA-MB-231 cells. Combined pretreatment with rosuvastatin 10 μM and meloxicam 50 μM notably enhanced genotoxicity while reducing colony formation, catalase activity, and SOD activity compared to radiotherapy alone in MCF-7, T-47D, and MDA-MB-231 cell lines.
Authors
- Zahra Babajani
- Arvin Naeimi (ORCID: https://orcid.org/0000-0002-8659-9549)
- Hamid Saeidi Saedi (ORCID: https://orcid.org/0000-0002-0910-7811)
- Kimia Shabani
- Amir Mohsen Bakhtiyari
- Mona Haddad Zahmatkesh
Institutions
- Guilan University of Medical Sciences (IR)
Publication Details
- Journal
- Research in Pharmaceutical Sciences
- Published
- 2025-12-26
- DOI
- https://doi.org/10.4103/rps.rps_191_24
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00