Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish
These findings suggest that lrrtm4l1 is an important regulator of social behaviour in zebrafish. In a translational perspective, LRRTM4 is a promising potential therapeutic target that warrants further investigation in the framework of neuropsychiatric conditions characterized by major social impairments.
Authors
- Jon H. Wetton (ORCID: https://orcid.org/0000-0001-8337-4654)
- Matthew O. Parker (ORCID: https://orcid.org/0000-0002-7172-5231)
- Guido Petracco
- William Norton (ORCID: https://orcid.org/0000-0002-3244-0145)
- Florian Reichmann (ORCID: https://orcid.org/0000-0002-5833-3698)
- Courtney Hillman (ORCID: https://orcid.org/0000-0003-4787-7400)
- María Florencia Scaia (ORCID: https://orcid.org/0000-0003-4069-5567)
- Elisa Dalla-Vecchia
- Barbara D. Fontana
Institutions
- University of Leicester (GB)
- Medical University of Graz (AT)
- University of Surrey (GB)
- Universidade Federal de Santa Maria (BR)
- BioTechMed-Graz (AT)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1016/j.nbd.2025.107251
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00