Safety and efficacy of combined heparin/citrate anticoagulation for cell therapy collections in healthy adult allogeneic donors

Heparin/citrate anticoagulation was safe, with lower heparin infusion rates, anti-Xa levels, and less prolonged aPTT than those observed in autologous adult donors. The good correlation between aPTT and anti-Xa levels suggests that aPTT levels can be used to estimate anti-Xa levels. Collection efficiencies of mononuclear cell types on heparin/ACD-A anticoagulation should be further explored.