Contribution of Amyloid Precursor Protein towards Mitochondrial Dysfunction in Alzheimer's Disease
Our findings suggest that APP and PGAM5 interact under physiological conditions. In AD, the decreased cleavage of PGAM5 may impair mitophagy, contributing to the mitochondrial dysfunction seen in AD pathogenesis. Precise understanding of the interaction of APP with other proteins, like PGAM5 is critical to ensure the long-term safety of potential treatments like APP knockdown in AD patients.
Authors
- Heather C. Rice (ORCID: https://orcid.org/0000-0002-5818-4338)
- Dylan Barber
- Casandra Salinas Salinas
- Zhi Zhang (ORCID: https://orcid.org/0000-0002-0190-1332)
- Samah Houmam (ORCID: https://orcid.org/0000-0002-8036-321X)
- Kriti Shukla
- Jialing Lin
- Dominika Siodlak
Institutions
- Oklahoma Medical Research Foundation (US)
- University of Oklahoma Health Sciences Center (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103247
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00