Comparison of thickness changes in retinal nerve fibre layer in Leber’s hereditary optic neuropathy patients with 11778, 14484 and 3460 mutations
The papillomacular bundle was the initial and preferential site of involvement in LHON patients across all mutation types. The pattern of RNFL involvement was similar among the three mutations: temporal quadrant thinning occurred first, followed by the inferior and superior quadrants, and finally the nasal quadrant. Patients with G11778A and G3460A mutations exhibited earlier and more pronounced RNFL atrophy compared to those with T14484C mutations.
Authors
- Nan Ma (ORCID: https://orcid.org/0000-0003-0783-5054)
- Hua Yuan (ORCID: https://orcid.org/0000-0002-3412-6205)
- Jie Hong (ORCID: https://orcid.org/0009-0000-3855-535X)
- Hongli Liu (ORCID: https://orcid.org/0000-0001-7118-4220)
- Jiajia Yuan
- Tao Zhang
- Meng-Lan Chen
- Dan Wang
- Bin Li
Institutions
- Fudan University (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Wuhan Children's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Translational Pediatrics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tp-2025-589
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00