Effects of EPA+DHA and Corn Oil Supplementation on PUFA Concentrations across Plasma Lipid Pools and on Downstream Oxylipins: Exploratory Results from a Randomized Controlled Trial in Healthy Humans
These findings offer insights into supplemental EPA+DHA localization to different circulating lipid pools, which have implications for understanding how to mitigate systemic inflammation. Furthermore, studies are needed to evaluate relationships between the changes in polyunsaturated fatty acids, oxylipins, and markers of inflammation. The study was registered at www.isrctn.com as ISRCTN96712688.
Authors
- Elizabeth A. Miles (ORCID: https://orcid.org/0000-0002-8643-0655)
- Saame Raza Shaikh (ORCID: https://orcid.org/0000-0003-1950-2521)
- Carolina Paras-Chavez
- Caroline E. Childs (ORCID: https://orcid.org/0000-0001-6832-224X)
- Helena L. Fisk (ORCID: https://orcid.org/0000-0002-9534-3246)
- Philip C. Calder (ORCID: https://orcid.org/0000-0002-6038-710X)
- Paul S Noakes
- Michael Armstrong
- Neha Balakrishnan
- Nicole Reisdroph
Institutions
- University of North Carolina at Chapel Hill (US)
- University Hospital Southampton NHS Foundation Trust (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- University of Southampton (GB)
- University of Colorado Anschutz Medical Campus (US)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1016/j.tjnut.2025.101274
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- University of Southampton
- European Commission
- National Institute for Health Research Southampton Biomedical Research Centre
- National Institutes of Health