Identification and Functional Characterization of the Axolotl ( <i>Ambystoma mexicanum</i> ) Tau Protein

Our microscopy data suggests that tau and β-tubulin III co-localize in axolotl brain tissue. These results will further elucidate our understanding of tau-microtubule interactions in the axolotl, unveil axolotl tau's capacity for aggregation, and position the axolotl as a novel model system in which to investigate how a regenerative organism might respond to an attempt to induce tauopathy.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_103601
Primary Topic
Alzheimer's disease research and treatments
Type
article
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article

Identification and Functional Characterization of the Axolotl ( Ambystoma mexicanum ) Tau Protein

Benoit I. Giasson, Zachary Strickland, Jada Lewis
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Identification and Functional Characterization of the Axolotl ( Ambystoma mexicanum ) Tau Protein

Benoit I. Giasson, Zachary Strickland, Jada Lewis
article en

Abstract

Our microscopy data suggests that tau and β-tubulin III co-localize in axolotl brain tissue. These results will further elucidate our understanding of tau-microtubule interactions in the axolotl, unveil axolotl tau's capacity for aggregation, and position the axolotl as a novel model system in which to investigate how a regenerative organism might respond to an attempt to induce tauopathy.

Alzheimer s & DementiaVol. 21(S1)
University of Florida (US)
Openalex Percentile: Top 32%
Alzheimer's disease research and treatments
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