Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction
Our study establishes the killifish as a translational model for investigating kidney vascular aging. SGLT2i preserves kidney microvascular structure and function, reduces proteinuria, and maintains a more youthful transcriptome. These results support a vascular-protective role of SGLT2i in mitigating age-related kidney deterioration.
Authors
- Heiko Schenk (ORCID: https://orcid.org/0000-0003-2693-5712)
- Cory P. Johnson (ORCID: https://orcid.org/0000-0002-6184-2290)
- Laura L. Beverly-Staggs
- Joel H. Graber (ORCID: https://orcid.org/0000-0001-5137-4553)
- Anchal Mahajan
- Hannah Somers (ORCID: https://orcid.org/0000-0002-1151-2656)
- H. Haller
- Anastasia Paulmann (ORCID: https://orcid.org/0000-0001-5400-0792)
- Ryan P. Seaman
- Matthew Cox (ORCID: https://orcid.org/0000-0001-8829-9999)
- Heath Fuqua
- Sonia Sandhi
- Tom Jannek Boewer
Institutions
- Mount Desert Island Biological Laboratory (US)
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- Kidney International
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.kint.2025.12.011
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00