Activation of aryl hydrocarbon receptor signaling by indole-3-lactic acid from Bacillus velezensis DS2 reinforces gut mucosal immunity and attenuates inflammaging in aged mice
We demonstrate that DS2 mitigates inflammaging by producing ILA, which acts as a key metabolite to activate the AhR-IL-22-ILC3 axis. Our findings highlight the potential of targeting the gut-immune axis with specific probiotics as a novel strategy against age-related immune decline.
Authors
- Qian Hou (ORCID: https://orcid.org/0009-0000-8759-5040)
- Xiaofeng Liu (ORCID: https://orcid.org/0000-0002-8378-9558)
- ZeJun Zhou
- Yongping Bai
- Jipeng Zhou
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s12979-025-00552-6
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00