Human milk oligosaccharides modulate inflammatory responses and lipid metabolism in a human intestinal organoid model

By utilizing advanced IEOs derived from fetal and pediatric patients, we reveal that this HMO blend elicits developmental-stage-specific responses. Our study highlights the potential of HMOs to support gut health, demonstrating their ability to enhance lipid metabolism and mitigate inflammatory damage. These findings offer important insights into the role of HMOs in early-life nutrition, lending compelling evidence to support their inclusion as key components in innovative and tailored infant nutrition strategies.