Metabolomics and lipidomics study on serum metabolite signatures in Alzheimer's disease and mild cognitive impairment

In summary, this novel study combing metabolomics and lipidomics approaches and found that perturbations in serum sphignolipids, glycerophospholipids, AAs, FFA and acylcarnitines are consistently associated with pathology and progression of AD and MCI. These metabolic biomarkers provided promising molecular targets for the early diagnosis and treatment of AD and MCI.