Effects of ketamine enantiomers on morphine and THC subjective effects in rats

These findings indicate that ketamine isoforms do not produce opioid- or cannabis-like subjective effects and are unlikely to fully mask the interoceptive effects of morphine or THC. However, their coadministration with cannabinoids may lead to pronounced sedative-like suppression. This warrants further investigation into the safety and interaction profiles of such drug combinations, particularly in therapeutic settings.

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Publication Details

Journal
Journal of Psychopharmacology
Published
2025-12-26
DOI
https://doi.org/10.1177/02698811251406839
Primary Topic
Treatment of Major Depression
Type
article
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article

Effects of ketamine enantiomers on morphine and THC subjective effects in rats

K. Starowicz, Adam Bisaga, P. Popik, Paweł Zajdel et al.
Journal of Psychopharmacology
Treatment of Major Depression
article

Effects of ketamine enantiomers on morphine and THC subjective effects in rats

K. Starowicz, Adam Bisaga, P. Popik, Paweł Zajdel, Joanna Golebiowska, Natalia Malikowska-Racia
article en

Abstract

These findings indicate that ketamine isoforms do not produce opioid- or cannabis-like subjective effects and are unlikely to fully mask the interoceptive effects of morphine or THC. However, their coadministration with cannabinoids may lead to pronounced sedative-like suppression. This warrants further investigation into the safety and interaction profiles of such drug combinations, particularly in therapeutic settings.

Journal of Psychopharmacology
Jagiellonian University (PL), New York Psychoanalytic Society and Institute (US), Maj Institute of Pharmacology (PL), Polish Academy of Sciences (PL)
Reduced inequalities
Openalex Percentile: Top 30%
Treatment of Major Depression
DOIOpen Access PDFOpenAlex
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Effects of ketamine enantiomers on morphine and THC subjective effects in rats — K. Starowicz, Adam Bisaga, et al. · Journal of Psychopharmacology (2025) | TGRS Research Map | TGRS