Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
TSR and DR are independent prognostic factors for cancer-specific survival. SMAPS is a promising prognostic tool that integrates stromal maturity at the invasive margin and stromal proportion in the tumour centre. SMAPS has stronger prognostic value compared to TSR and DR classifications alone. A high stromal proportion and myxoid content are associated with an immunosuppressive microenvironment characterized by lower densities of antitumourigenic immune cells.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- Ville K. Äijälä (ORCID: https://orcid.org/0009-0005-7664-8027)
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Tero Rautio (ORCID: https://orcid.org/0000-0003-4441-9412)
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Meeri Kastinen (ORCID: https://orcid.org/0009-0007-0954-5612)
- Sanna Meriläinen (ORCID: https://orcid.org/0000-0002-0789-9042)
- Markus J. Mäkinen (ORCID: https://orcid.org/0000-0002-9200-4118)
- Mecklin Jukka-Pekka
- Päivi Sirniö (ORCID: https://orcid.org/0000-0002-3988-3782)
- Taneli T. Mattila
- Henna Karjalainen (ORCID: https://orcid.org/0009-0008-4694-6703)
- Jukka M. J. Rintala (ORCID: https://orcid.org/0000-0003-1865-8444)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Anne Tuomisto (ORCID: https://orcid.org/0000-0002-9949-1887)
- Outi Lindgren (ORCID: https://orcid.org/0000-0002-2130-5714)
- Vilja V. Tapiainen (ORCID: https://orcid.org/0009-0003-6306-6525)
- Onni Sirkiä (ORCID: https://orcid.org/0009-0003-8142-7144)
- Vesa-Matti Pohjanen
- Toni T. Seppälä
- Jan Böhm
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- Department of Social Services (AU)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1080/07853890.2025.2606512
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00