Sex differences among patients with giant cell arteritis: insights from the Spanish ARTESER Registry

Women more frequently exhibited the extracranial phenotype, required more csDMARDs, and experienced a higher incidence of fractures. In contrast, men more commonly presented with the mixed phenotype, had more cataracts, and showed a higher mortality rate. These findings highlight the importance of integrating sex as a key biological variable in GCA research and clinical management to support more tailored and effective therapeutic strategies.

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Lara D. Veeken
Published
2025-12-24
DOI
https://doi.org/10.1093/rheumatology/keaf689
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
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article

Sex differences among patients with giant cell arteritis: insights from the Spanish ARTESER Registry

Marta Domínguez-Álvaro, F. Sánchez-Alonso, Ana Paula Cacheda, E. De Miguel et al.
Lara D. Veeken
Vasculitis and related conditions
article

Sex differences among patients with giant cell arteritis: insights from the Spanish ARTESER Registry

Marta Domínguez-Álvaro, F. Sánchez-Alonso, Ana Paula Cacheda, E. De Miguel, J Urgellés, Elisa Fernández-Fernández, C. Larena Grijalba, Ismael González Fernández, Cristina Valero Martínez, J. Mendizabal, Íñigo Hernández-Rodríguez, N. Garrido-Puñal, Nair Torrado Pérez, E Cortina, V. Angeles, José L. Hernández, María Jesús García-Villanueva, J Narvaez, Maite Silva-Díaz, Joaquín Belzunegui, I. Calvo, Vicente Aldasoro, Julio Sánchez Martín, Amalia Sanchez-Andrade Fernández, Clara Moriano, Noelia Alvarez Rivas, J. Loricera, J. L. Filloy, Lucia Silva Fernández, Clara Aguilera Cros, Alberto Ruiz Román, Paula Estrada Alarcón, T. Pérez Sandoval, M. Alcalde Villar, Clara Molina Almela, D. Fernandez-Lozano, Leticia Leon Mateos, Ana Milena Millán, Javier Calvo Catalá, Félix Cabero del Pozo, Alejandro Muñoz Jimenez, Anderson Huaylla, Ana Belén Rodríguez Cambrón, Santos Castañeda, E. Díez Álvarez, Ana F Cruz Valenciano, Ricardo Blanco, Lydia Abasolo, Patricia Moya-Alvarado, ARTESER Project Collaborative Group, María Sagrario Bustabad Reyes, Rafael Benito Melero, Selene Labrada Arrabal, Loreto Horcada Rubio, Jaime Calvo Allen, Tomás Almorza, Tarek Carlos Salman Monte, Aliuska Palomeque Vargas, Marta Serrano Warleta, Tomás Ramón Vázquez Rodríguez, Ceferino Barbazán, Jose A Román Ivorra, Berta Magallares, Carlota Laura Iñiguez Ubiaga, Vette Casafont, John Guzman, Cesar Antonio Egues Dubuc, Amalia Rueda Cid, María García González, Inmaculada Paniagua Zudaire, Miren Uriarte-Ecenarro, Cristina Macia Villa, Ricardo Gutiérrez Polo, Joan Calvet Fontova, Carlos García Porrúa, Patricia Carreira, Pia Mercedes Lois Bermejo, Laura Garrido Courel, Vanesa Hernández Hernández, Judit Lluch, Francisco Ortiz Sanjuán, Eva Álvarez de Andrés, Inmaculada Ros Vilamajó, Jordi Camins, Luis López Domínguez, Cristina Campos Fernández, María Concepción Fito Manteca, Antonio Juan Mas, Elide Toniolo, Carlos Galisteo Lencastre Da Veiga, Marina Tortosa Cabañas
article en

Abstract

Women more frequently exhibited the extracranial phenotype, required more csDMARDs, and experienced a higher incidence of fractures. In contrast, men more commonly presented with the mixed phenotype, had more cataracts, and showed a higher mortality rate. These findings highlight the importance of integrating sex as a key biological variable in GCA research and clinical management to support more tailored and effective therapeutic strategies.

Lara D. VeekenVol. 65(1)
Universidad de Cantabria (ES), Hospital Universitario La Paz (ES), Hospital de Sant Pau (ES), Bellvitge University Hospital (ES), University Hospital Complex Of Vigo (ES), Hospital Clínico San Carlos (ES), Hospital Universitari i Politècnic La Fe (ES), Complejo Hospitalario de Navarra (ES), Marqués de Valdecilla University Hospital (ES), Sociedad Española de Reumatología (ES), Instituto de Investigación Marqués de Valdecilla (ES), Hospital de Galdakao (ES), Hospital Universitario de La Princesa (ES), Hospital de Sant Joan Despí Moisès Broggi (ES), Donostiako Unibertsitate Ospitalea (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitario de León (ES), Hospital Universitario Ramón y Cajal (ES)
Good health and well-being
Openalex Percentile: Top 28%
Vasculitis and related conditions
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