Granulometric Analysis After Spontaneous Disintegration of Tablets Containing Micronized Purified Flavonoid Fraction (SIZE Study)
The SIZE study highlights the importance of particle size in drug solubility and bioavailability, suggesting that differences in the micronization process affect therapeutic efficacy. The findings underscore the need for standardized regulations on micronization to ensure product consistency.
Authors
- Luiz Cláudio Rodrigues Pereira da Silva (ORCID: https://orcid.org/0000-0002-6746-5756)
- Isabella Mourão Machado Valle (ORCID: https://orcid.org/0000-0002-7234-7260)
- Raianne Soares Rebelo
- Estefane Theophilo de Freitas Pereira
- Renata Lima
- Adriane dos Santos Francisco
- Juliana Alves Ferreira
- João Vitor Santana da Silva
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Cureus
- Published
- 2025-12-27
- DOI
- https://doi.org/10.7759/cureus.100169
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00