Identification of novel fibroblast subsets in diffuse cutaneous systemic sclerosis
Our study identified novel fibroblast subsets in SSc, characterised by CD9 and/or FHL1 upregulation. The data indicate a functional role of FHL1 in fibroblasts and its involvement in the regulation of ECM production and provide a new mechanistic link to VGLL3 regulation. Our findings suggest new avenues for therapeutic exploration targeting the perpetuating fibroblast activation by the fibrotic environment.
Authors
- Bent Brachvogel (ORCID: https://orcid.org/0000-0002-3923-0554)
- Katrin Schönborn (ORCID: https://orcid.org/0000-0003-1819-8193)
- Till Baar (ORCID: https://orcid.org/0000-0002-6744-1463)
- Anna Bornikoel (ORCID: https://orcid.org/0000-0002-1921-7205)
- Achim Tresch (ORCID: https://orcid.org/0000-0002-4146-6371)
- Frederik Tellkamp (ORCID: https://orcid.org/0000-0002-0473-7320)
- Niklas Kleinenkuhnen (ORCID: https://orcid.org/0009-0002-5453-6081)
- Pia Moinzadeh (ORCID: https://orcid.org/0000-0002-8784-8615)
- Lena Keufgens (ORCID: https://orcid.org/0000-0001-6892-7302)
- Isabel Zeinert
- Beate Eckes
- Marcus Krüger
- Thomas Krieg
- Ann-Helen S Rosendahl
Institutions
- University of Cologne (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ard.2025.11.027
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Society for Infectious Diseases
- Deutsche Forschungsgemeinschaft
- Institut National de la Santé et de la Recherche Médicale
- Emil Aaltosen Säätiö
- European Society for Dermatological Research