The Effect of Weekend and Holiday Resistance Training Combined With a Low-Fat, High-Protein Diet on Endothelial Function, Hepatic Steatosis, and Overall Systemic Health: A Case Report

The combination of resistance training five or six times per week, along with a low-fat, high-protein diet, is known to promote weight loss and maintain muscle mass. However, for non-athletes, fully replicating this training and diet regimen is challenging. A 39-year-old overweight male was diagnosed with dyslipidemia, including hypertriglyceridemia and high low-density lipoprotein cholesterol, and metabolic dysfunction-associated steatotic liver disease (MASLD), and had decreased flow-mediated vasodilation (FMD). During the eight-month follow-up period, he engaged in resistance training during weekends and holidays in the early mornings, while adhering to a low-fat, high-protein diet. Throughout the follow-up, he underwent blood tests, abdominal ultrasonography, FMD, and body composition measurements every three months. He achieved weight loss, an increase in FMD, and improvements in blood lipid parameters and MASLD. This case suggests the potential benefits of our weight loss method. However, further clinical trials involving individuals with nonspecialized knowledge are needed to establish its general applicability.