Downregulation of ANPEP Is Associated with Aggressive Prostate Cancer and Poor Disease-specific Outcomes
We looked at levels of a protein called aminopeptidase N (ANPEP) in prostate tumors using information from large databases. We found that ANPEP is linked to markers that indicate more aggressive disease and that higher ANPEP levels are associated with more favorable treatment outcomes.
Authors
- Christopher J. Sweeney (ORCID: https://orcid.org/0000-0002-0398-6018)
- Alejandro G Berlin
- Jasreman Dhillon (ORCID: https://orcid.org/0000-0001-6785-3487)
- Asmaa El-Kenawi (ORCID: https://orcid.org/0000-0003-2039-2825)
- Esther N. Katende (ORCID: https://orcid.org/0000-0003-1490-1195)
- Kosj Yamoah (ORCID: https://orcid.org/0009-0001-0987-0972)
- Daniel Eidelberg Spratt (ORCID: https://orcid.org/0000-0002-5973-4741)
- Matthew R. Cooperberg (ORCID: https://orcid.org/0000-0003-4339-6685)
- Ryan M. Putney (ORCID: https://orcid.org/0000-0002-0468-736X)
- Amparo N. Serna (ORCID: https://orcid.org/0009-0006-8418-0433)
- Elai Davicioni
- Purvish Trivedi (ORCID: https://orcid.org/0009-0003-0351-6627)
- Paul L. Nguyen
- Monica Ryu
- Shivanshu Awasthi
- Jong Y. Park
- R. Jeffrey Karnes
- Timothy R. Rebbeck
- James Proudfoot
Institutions
- University of California, San Francisco (US)
- University of Toronto (CA)
- Australian Institute of Business (AU)
- Moffitt Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- University Hospitals Seidman Cancer Center (US)
- Veracyte (United States) (US)
- Mayo Clinic in Arizona (US)
- Centre for Cancer Biology (AU)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1016/j.euros.2025.12.011
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00