Fatal Glyphosate Poisoning Presenting with Myocarditis and Multiorgan Failure: A Case Report

Glyphosate-based Herbicides (GBHs) are widely used agricultural chemicals linked to increasing reports of intoxications. Disruption of oxidative phosphorylation, along with cardiotoxic effects related to polyoxymethylene amines, is considered to play a role in the toxic actions of Glyphosate (GLY). The present case reports reveal a fatal case of GLY poisoning in a 34-year-old male who ingested approximately 100 mL of Roundup herbicide containing 41% GLY. Despite aggressive medical and supportive management, the patient's condition rapidly deteriorated, leading to multi-organ failure and death. Laboratory investigation revealed severe leukocytosis, electrolyte derangements, hepatic dysfunction, as well as cardiac injury, with elevated troponin I and CK-MB levels, and 2D echocardiography presented global Left Ventricular (LV) hypokinesia with an Ejection Fraction (EF) of 25%. This case highlights the potential lethality of GLY poisoning and the importance of prompt recognition and treatment, as in this case patient reported approximately 25 hours after ingestion. The findings suggest that GLY toxicity can cause severe systemic inflammation, myocardial injury, and multi-organ failure, leading to a poor prognosis. This case report aims to increase awareness about the severity of GLY poisoning and the emphasis the early intervention and aggressive management.