CDCA3 Regulates Tumor-Associated Macrophages Polarize to Promote the Malignant Progression of Hepatocellular Carcinoma
Our findings suggest that CDCA3 promotes the malignant progression of HCC by driving M2-like TAM polarization, potentially through the upregulation of cytokines such as TGF-β1, VEGFA, CD40, CXCL1, and CXCL5. CDCA3 thus represents a promising diagnostic biomarker and therapeutic target for HCC.
Authors
- Daochang Zhang (ORCID: https://orcid.org/0000-0002-9648-362X)
- Hongkun Xu
- Shanmei Lyu
- Li Zhang (ORCID: https://orcid.org/0000-0003-1126-3300)
- Juan Lyu (ORCID: https://orcid.org/0000-0002-1366-1807)
- Enqin Wang
- Zhijun Fang
Institutions
- First People’s Hospital of Zunyi (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jhc.s559772
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00