Glioblastoma as Homeostatic Hijacking A Systems-Level Application of the Clinical Homeostasis Framework

Glioblastoma multiforme (GBM) remains one of the most treatment-resistant human cancers despite extensive molecular and clinical investigation. This paper applies the Clinical Homeostasis framework to examine whether GBM persistence and therapeutic resistance may reflect stabilisation within, and exploitation of, existing regulatory systems of the brain rather than simple failure of control. Drawing on peer-reviewed literature, the analysis synthesises evidence relating to vascular co-option, immune microenvironment reprogramming, metabolic adaptation, and stem-cell niche protection. The concept of “homeostatic hijacking” is proposed as a falsifiable research lens rather than a causal or therapeutic claim. This work does not propose treatments, diagnostics, or clinical interventions, and is intended solely as a conceptual contribution to systems-level cancer research.