Centiloid levels predict altered brain microstructure in adults without dementia
Aβ neuropathology is associated with altered white matter organization in community-dwelling adults without dementia. Fiber dispersion is a novel dMRI measure with exceptional correspondence to Aβ-PET centiloid levels and cognition, independent of age and sex. Modeling fiber density and dispersion afford complementary insights about microstructural changes associated with Alzheimer's pathology and cognitive function.
Authors
- Pavithran Pattiam Giriprakash
- Andrew R. Bender (ORCID: https://orcid.org/0000-0003-2710-3571)
- Jessica ZK Caldwell
- Zhengshi Yang
- Dietmar Cordes
Institutions
- Cleveland Clinic (US)
- Lou Ruvo Brain Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104522
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00