Features of IgG4-related sclerosing mesenteritis: A Chinese cohort study and literature review
IgG4-SM is a significant but under-recognized manifestation of IgG4-RD, characterized by a predilection for elderly males, multi-organ involvement, higher disease activity and distinct imaging features. Systemic radiological evaluation, including PET-CT could assist diagnosis and treatment monitoring. Glucocorticoid-based therapy achieved outcomes comparable to surgery, challenging the necessity of invasive interventions. This study expands the clinical spectrum of IgG4-SM and advocates for personalized, non-surgical management strategies in most cases.
Authors
- Qinhuan Luo (ORCID: https://orcid.org/0000-0001-8011-4136)
- Nianyi Zhang
- Yifei Wang (ORCID: https://orcid.org/0000-0002-1674-4763)
- Wen Zhang
- Jialing Jiang
- Jiaxin Zhou
- Yuxue Nie
- Jialei Zhang
- Linyi Peng
- Xinli Yang
- Jingna Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Rheumatology and Immunology Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1515/rir-2025-0026
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Peking Union Medical College Hospital
- Peking Union Medical College