Identification of novel <i>FGFR2::TXLNB</i> Fusion in a polymorphous low‐grade neuroepithelial tumor of the young
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Authors
- Bo Wang (ORCID: https://orcid.org/0000-0003-3042-769X)
- Shasha Hu (ORCID: https://orcid.org/0000-0001-6926-0984)
- Tian‐Yuan Tan
- Wei Yan
Institutions
- Hainan General Hospital (CN)
- Southern Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Brain Pathology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1111/bpa.70063
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00