Amino Acid Signaling in Skeletal Muscle Is Blunted by Prematurity in a Piglet Model
PT birth impairs the abundance and activation of multiple amino acid-sensing components upstream of mTORC1 in skeletal muscle. This disruption attenuates amino acid-induced mTORC1-dependent translation initiation and protein synthesis and likely contributes to the anabolic resistance, reduced lean mass, and extrauterine growth faltering frequently observed in premature infants.
Authors
- Rosemarie D Parada
- Marta L. Fiorotto (ORCID: https://orcid.org/0000-0001-8475-4704)
- Teresa A. Davis (ORCID: https://orcid.org/0000-0002-4610-9795)
- Agus Suryawan
- Antonio C. Ramos dos Santos
- Ki Beom Jang
- Mahmoud A. Mohammad
Institutions
- Seoul National University (KR)
- Texas A&M University System (US)
- Center for Advancing Health (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1016/j.tjnut.2025.101303
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture