Comparative analysis of IHC, AMRS-PCR, and ddPCR for BRAF V600E mutation detection in papillary thyroid carcinoma
AMRS-PCR provides greater sensitivity and specificity than IHC for detecting BRAF V600E mutations and is appropriate for routine molecular testing. ddPCR offers excellent sensitivity for low-frequency mutations and is valuable for resolving discordant results. A multimodal testing strategy may improve detection accuracy and support personalized management of patients with PTC.
Authors
- G Wang (ORCID: https://orcid.org/0000-0002-2777-4191)
- Jianyuan Lei
- Lele Liu
- Chen Chang
- Wensheng Li
- Guodong Fang
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1016/j.ctarc.2025.101085
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00