Longitudinal changes in frailty, insulin resistance and incident cardiovascular-kidney- metabolic syndrome progression in middle-aged and older adults: evidence from CHARLS
Both baseline frailty and its progression over time were independently associated with an elevated risk of advanced CKM syndrome. IR was identified as a partial mediator in this relationship. This finding suggests that IR may serve as a modifiable biological target for intervention.
Authors
- Zheng Liu (ORCID: https://orcid.org/0000-0003-1175-0459)
- H Li
- X Y Zhang
- Muhan Lü
- Wanmeng Xiao
- Song Su (ORCID: https://orcid.org/0000-0001-9119-4995)
- Tao Yang (ORCID: https://orcid.org/0000-0002-5627-2457)
- Xian Luo
- Mingzhu Xiu
- X. Li Qing
- Qi Huang
- Sha Liu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s13098-025-02030-x
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00