Gold-Catalyzed Regioselective <i>N</i> -1 Arylation of Indazoles
We have developed a ligand-enabled Au(I)/Au(III) catalyzed <i>N</i>-1 arylation of indazoles using aryl iodides as electrophile reagents. This transformation proceeds with excellent regioselectivity and a broad substrate scope, tolerating both aryl iodides with diverse electronic properties (e.g., -Br, Cl, -CO<sub>2</sub>Me, -CHO) and a wide range of indazole derivatives.
Authors
- Jiawen Wu (ORCID: https://orcid.org/0000-0001-7448-3605)
- Zhonghua Xia
- Gang Li
Institutions
- Beijing Institute of Technology (CN)
- Tangshan College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1021/acs.joc.5c02836
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00