Proteomic comparison of intact and fetoscopy-induced fetal membrane defect sites
By combining untargeted proteomics with histological and qPCR evaluations, this study demonstrates subtle molecular and cellular changes in fetoscopy-induced fetal membrane defects at the time of delivery. This indicates minimal molecular and cellular healing mechanisms in the fetal membranes. This underscores the potential for sealing FM defects after fetoscopy to prevent amniotic fluid leakage, thereby reducing the incidence of intra-amniotic preterm rupture of membranes.
Authors
- Lukas O. Moser (ORCID: https://orcid.org/0000-0001-7167-3577)
- Bernd Roschitzki (ORCID: https://orcid.org/0000-0001-5756-9773)
- Martin Ehrbar (ORCID: https://orcid.org/0000-0003-2707-4870)
- Ladina Rüegg (ORCID: https://orcid.org/0000-0002-4663-9614)
- Jonas Grossmann (ORCID: https://orcid.org/0000-0002-6899-9020)
- Nicole Ochsenbein-Kölble
- Eva Avilla-Royo
- Katharina Gegenschatz-Schmid
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1038/s41390-025-04692-9
- Citations
- 1
- Primary Topic
- Assisted Reproductive Technology and Twin Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Universität Zürich