Grip Strength Normalized by Lean Body Mass: A Novel Biomarker for Cognitive Health in Older Adults
Grip/LBM emerged as a robust predictor of cognitive health, outperforming grip strength or lean body mass alone. These findings suggest that neuromuscular function, as reflected by Grip/LBM, may serve as a surrogate marker for brain neuronal integrity. This metric offers potential as a practical biomarker for cognitive health and a target for interventions aimed at mitigating cognitive decline.
Authors
- Nicole Anderson
- Dvir Dori (ORCID: https://orcid.org/0009-0004-5332-3636)
- Danielle D'Amico
- Brian Tan
- Maliha Chowdhury
- Howard Chertkow
Institutions
- University of Toronto (CA)
- Baycrest Hospital (CA)
- Occupational Cancer Research Centre (CA)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103922
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00