Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia
This study supports the superior performance of the 'six-point' system for transformation prediction on a multicentric sample. Findings indicate that feature-specific models may be more reliable than existing histological grading systems for prognosis prediction.
Authors
- Hisham Mehanna (ORCID: https://orcid.org/0000-0002-5544-6224)
- Paul Nankivell (ORCID: https://orcid.org/0000-0003-4664-6117)
- Jacqueline A. James
- Omar Kujan (ORCID: https://orcid.org/0000-0002-5951-8280)
- Pablo Agustin Vargas
- Mike Bradburn
- Syed Ali Khurram
- Nadim Islam
- Nasir Rajpoot
- Alan Roger Santos‐Silva
- Hanya Mahmood
Institutions
- Queen's University Belfast (GB)
- The University of Western Australia (AU)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Florida (US)
- University of Warwick (GB)
- Cancer Research UK Clinical Trials Unit (GB)
- University of Birmingham (GB)
- University of Warwick Science Park (GB)
- University of Sheffield (GB)
- Florida College (US)
Publication Details
- Journal
- Oral Diseases
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1111/odi.70173
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Seagen
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council