Baseline amyloid spatial extent in combination with tau burden captures cognitive decline, measured digital clock drawing test and PACC5, in preclinical Alzheimer's disease
Longitudinal assessment with DCTclock captured unique information about cognitive decline in the early stages of the spread of amyloid. However, the PACC remained a superior measure of the more severe cognitive decline associated with amyloid and tau pathology in later stages of preclinical AD.
Authors
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Dana L. Penney (ORCID: https://orcid.org/0000-0003-3105-6974)
- Jessie Fanglu Fu (ORCID: https://orcid.org/0000-0002-4970-7811)
- Jackson Thompson
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- Julie C. Price
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Marina Álvarez Alonso
- Grace A Del Carmen Montenegro
- Elliott Slade
- Michelle E. Farrell
- Randall Davis
- Keith A. Johnson
- Reisa A. Sperling
- Dorene M. Rentz
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Lahey Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106687
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00