Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury
In conclusion, targeting the Sirt1/Nrf2 signaling pathway, as demonstrated by APRE in our model, could present a promising therapeutic target to protect against HIR-induced liver injury during major liver surgeries.
Authors
- Mina Kelleni (ORCID: https://orcid.org/0000-0001-6290-6025)
- Mina Ezzat Attya
- Walaa Yehia Abdelzaher (ORCID: https://orcid.org/0000-0001-6511-1797)
- Mohamed Ibrahim (ORCID: https://orcid.org/0000-0002-3203-944X)
- Michael Atef Fawzy (ORCID: https://orcid.org/0000-0002-0456-9021)
- Marly Nady Adly (ORCID: https://orcid.org/0009-0001-0292-419X)
Institutions
- Minia University (EG)
Publication Details
- Journal
- World Journal of Hepatology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.4254/wjh.v17.i12.110733
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00