Multimodal functional neuroimaging of hippocampal engagement in cognitively normal older individuals
The importance of these results is multifaceted. First, we defined a direct neural read-out of hippocampal activity in MEG that can index memory processes known to be affected in AD pathology. Second, we demonstrated the relationship between two complementary measures of hippocampal engagement (fMRI pattern separation, MEG repetition suppression) and their association to lure discrimination performance. Third, we established a normative distribution of both putative biomarkers that can be used for participant selection in future intervention trials.
Authors
- Kevin Grant Solar (ORCID: https://orcid.org/0000-0002-4072-6645)
- Sriranga Kashyap (ORCID: https://orcid.org/0000-0003-0307-9773)
- Ljubica Zotovic
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Melisa Gumus (ORCID: https://orcid.org/0000-0003-2478-2572)
- Nicolas Deom
- Richard Wennberg (ORCID: https://orcid.org/0000-0002-1865-2280)
- Luís Garcia Dominguez
- Mary Pat McAndrews
- Kamil Uludag
- Sandra E. Black
Institutions
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102965
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00