Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease

The graded distinctions amongst typical amnestic and atypical phenotypes of AD support the proposal for a transdiagnostic, multidimensional phenotype geometry that spans all AD subtypes. Inclusion of all AD phenotypes in clinical trials and treatments is critical with a particular focus on transdiagnostic symptoms, considering their relevance to disease burden and interventions.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_103552
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease

Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease

article en

Abstract

The graded distinctions amongst typical amnestic and atypical phenotypes of AD support the proposal for a transdiagnostic, multidimensional phenotype geometry that spans all AD subtypes. Inclusion of all AD phenotypes in clinical trials and treatments is critical with a particular focus on transdiagnostic symptoms, considering their relevance to disease burden and interventions.

Alzheimer s & DementiaVol. 21(S3)
University of Cambridge (GB), Bridge University (SS)
Quality Education
Openalex Percentile: Top 32%
Dementia and Cognitive Impairment Research
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Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS