Clinicopathologic Features of Six Patients With Metastatic Carcinoma to the Uterine Cervix

Metastasis to the female genital tract is a rare event and presents a significant diagnostic challenge. Among the organs of the female genital tract, the uterine cervix is an exceptionally uncommon site for metastasis, likely due to its limited vascular perfusion and abundant fibrous tissue. The most common clinical presentation is abnormal vaginal bleeding, seen in 62% to 75% of patients. Accurate identification of cervical tumors, whether primary or metastatic, is necessary for proper treatment and prognostic assessment. In this case series, we present the clinicopathologic features of six patients with metastatic cancer to the uterine cervix encountered over a 5-year period.

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Publication Details

Journal
International Journal of Surgical Pathology
Published
2025-12-26
DOI
https://doi.org/10.1177/10668969251405428
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
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article

Clinicopathologic Features of Six Patients With Metastatic Carcinoma to the Uterine Cervix

Manju Harshan, Ahmed Bendari, Tasneem Bendari, Reham Al-Refai et al.
International Journal of Surgical Pathology
Endometrial and Cervical Cancer Treatments
article

Clinicopathologic Features of Six Patients With Metastatic Carcinoma to the Uterine Cervix

Manju Harshan, Ahmed Bendari, Tasneem Bendari, Reham Al-Refai, Sham Sunder, Juan Luis Gomez Marti, Saroja Devi Geetha, Ryan Des Jean, H. M. Ahmed Mohamed, Beena Ahsan, Ramy Hiekel
article en

Abstract

Metastasis to the female genital tract is a rare event and presents a significant diagnostic challenge. Among the organs of the female genital tract, the uterine cervix is an exceptionally uncommon site for metastasis, likely due to its limited vascular perfusion and abundant fibrous tissue. The most common clinical presentation is abnormal vaginal bleeding, seen in 62% to 75% of patients. Accurate identification of cervical tumors, whether primary or metastatic, is necessary for proper treatment and prognostic assessment. In this case series, we present the clinicopathologic features of six patients with metastatic cancer to the uterine cervix encountered over a 5-year period.

International Journal of Surgical Pathology
Northwell Health (US), Memorial Sloan Kettering Cancer Center (US), Montefiore Medical Center (US), NewYork–Presbyterian Brooklyn Methodist Hospital (US), Henry Ford Health System (US), Zagazig University (EG), Long Island Jewish Medical Center (US), Lenox Hill Hospital (US), Michigan State University (US), Sohag University (EG)
Good health and well-being
Openalex Percentile: Top 26%
Endometrial and Cervical Cancer Treatments
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