Impaired glymphatic function exacerbates tau propagation and the effect of tau pathology on cognitive decline in Alzheimer's disease

Our findings suggested that impaired glymphatic system might plays an adverse role on cognitive function and clinical progression via alleviating tau clearance from the inter-neuronal space, which may also facilitate the tau spread. The current results provide novel understanding of clearance mechanism of tau pathology and encourage future work to develop glymphatic system-targeted therapy for AD.