Alzheimer's disease is associated with changes in the metabotropic glutamate mGlu3 receptor expression but not with SNPs in the GRM3 gene
We suggest that early changes in glial mGlu3R expression in AD deprive the brain of the neuroprotective and anti-amyloidogenic mechanisms executed by the receptor, and this may be involved in the etiology of the disease.
Authors
- Daniela Durand (ORCID: https://orcid.org/0000-0003-2361-1165)
- Juan Beauquis (ORCID: https://orcid.org/0000-0003-1404-5632)
- Mercedes Lasaga (ORCID: https://orcid.org/0000-0001-9916-3712)
- Daniela Karina Zelaya
- Albany Sáez
- A. Rodríguez Romero
- Eugenia Olivera
- Flavia Saravia
- Pilar Garaventa
- Carla Caruso
- Mercedes Bigi
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103132
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00