Unveiling Factors Contributing to Cortical Tau Tangle Accumulation and Spread Beyond β‐Amyloid in Alzheimer's Disease
These findings unveiled that longer education periods, lower plasma sTREM2 levels, higher plasma GFAP levels, and larger WMH burden are related to faster tau accumulation in AD in addition to Aβ pathology. This study emphasizes the importance of controlling these factors beyond Aβ to prevent tau aggregation in AD.
Authors
- Guoyu Lan (ORCID: https://orcid.org/0000-0003-2925-1738)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4346-9100)
- Tengfei Guo
- Yue Cai
Institutions
- Shenzhen Bay Laboratory (CN)
- Peking University Shenzhen Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101561
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00