QuantiFERON‐CMV Monitoring Post‐Allogeneic Hematopoietic Stem Cell Transplantation Is Dynamic and Predictive of Immediate Cytomegalovirus Outcomes
QFCMV reactivity was associated with lower peak CMV viral load but not csCMVi. Mitogen-stimulated IFNγ response correlated with csCMVi, suggesting a role for broader assessment of cellular immunity post-transplant. Despite incorporating adaptive immunity measures, QF-monitor was limited in assessing CMV risk. QFCMV reactivity was infrequently achieved in the early post-allogeneic stem cell transplant period. Qualitative QFCMV result was associated with peak CMV viral load but not clinically significant infection, while magnitude of the mitogen response predicted reduction in clinically significant CMV infection.
Authors
- Tim Spelman (ORCID: https://orcid.org/0000-0001-9204-3216)
- Jen Kok (ORCID: https://orcid.org/0000-0002-8796-283X)
- Monica A. Slavin (ORCID: https://orcid.org/0000-0002-8443-314X)
- A. Grigg
- Jason A. Trubiano (ORCID: https://orcid.org/0000-0002-5111-6367)
- Michelle Yong
- Chhay Lim (ORCID: https://orcid.org/0000-0003-4141-1765)
- Surekha Tennakoon
- Beatrice Sim (ORCID: https://orcid.org/0000-0003-1845-4476)
- Joe Sasadeusz (ORCID: https://orcid.org/0000-0001-7438-0382)
- Bruce Ritchie (ORCID: https://orcid.org/0000-0003-4754-1050)
- Violet Z. Zhu
- Siobhan Mineely
- Lynette Chee
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Austin Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Westmead Hospital (AU)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1111/tid.70152
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00