Inhibition of MDM2 by nutlin-3 decreased pyroptosis but increased apoptosis of lung carcinoma cells under 5-FU chemotherapy
GSDME-mediated pyroptosis plays a pivotal role in chemotherapy-induced cell death in lung adenocarcinoma. MDM2 inhibition, which switches pyroptosis to apoptosis, can be employed to regulate chemotherapy-induced pyroptosis in lung cancer cells and normal tissue cells.
Authors
- Tingting Hu
- Xiaoyu Duan
- Hongyi Cai
- Yafei Zhuang
Institutions
- Gansu Provincial Hospital (CN)
Publication Details
- Journal
- Journal of Cancer Research and Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.4103/jcrt.jcrt_2060_24
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00