Does Mood Matter: The impact of affective symptoms on the Digital Clock Test scores, a portable and sensitive screen for cognitive impairment
In older adults, greater depressive symptoms were associated with worse performance on both the DCT and standard cognitive screens (MMSE, PACC5). In contrast, both depressive and anxiety symptoms were associated with "impaired" scores on PACC5 and/or MMSE, but not on the DCT. This could suggest that the DCT is a sensitive cognitive screen for AD and related dementias in clinical settings where patients present with co-occurring mood disturbances.
Authors
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Jessie Fanglu Fu (ORCID: https://orcid.org/0000-0002-4970-7811)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- Gad Marshall
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Abigail LaCasse
- Catherine E Munro
- Natalie R Scher
- Deborah Blacker
- Dorene M. Rentz
- Reisa A. Sperling
- Kathryn V Papp
- Keith A. Johnson
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- William James College (US)
- McLean Hospital (US)
- Universidad de Antioquia (CO)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106486
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00