Developmental venous anomalies and cerebral cavernous malformations: Partners in crime

Developmental venous anomalies (DVAs) are benign congenital veins that collect normal brain drainage into a single outlet. Cerebral cavernous malformations (CMs) are clusters of thin-walled capillary cavities prone to bleeding. When both lesions coexist, the DVA's altered venous pressure and flow can promote CM formation or rupture. Detecting a DVA abutting an otherwise unexplained intracerebral hemorrhage can therefore raise suspicion of an occult CM as a likely cause, a clue which may be invaluable for daily clinical practice. The main focus of this review is to acknowledge the hallmark imaging appearances of DVAs and CMs, as well as their coexistence, explore the clinical consequences of mixed lesions, and emphasize that recognizing their partnership is vital for an accurate, timely diagnosis and appropriately targeted management.

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Publication Details

Journal
World Journal of Radiology
Published
2025-12-26
DOI
https://doi.org/10.4329/wjr.v17.i12.114595
Primary Topic
Vascular Malformations Diagnosis and Treatment
Type
article
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article

Developmental venous anomalies and cerebral cavernous malformations: Partners in crime

Evgenia Efthymiou, Olympia Papakonstantinou, Ilianna Tsetsou, Spyridon Prountzos et al.
World Journal of Radiology
Vascular Malformations Diagnosis and Treatment
article

Developmental venous anomalies and cerebral cavernous malformations: Partners in crime

Evgenia Efthymiou, Olympia Papakonstantinou, Ilianna Tsetsou, Spyridon Prountzos, Anastasia Karachaliou, Ανδρέας Παπαδόπουλος, Nikolaos Gouliopoulos, Dimitrios Filippiadis, Georgios Velonakis, Manos Siderakis, Nikolaos-Achilleas Arkoudis, Ornella Moschovaki-Zeiger, George Triantafyllou, Dimitrios Chalmoukis
article en

Abstract

Developmental venous anomalies (DVAs) are benign congenital veins that collect normal brain drainage into a single outlet. Cerebral cavernous malformations (CMs) are clusters of thin-walled capillary cavities prone to bleeding. When both lesions coexist, the DVA's altered venous pressure and flow can promote CM formation or rupture. Detecting a DVA abutting an otherwise unexplained intracerebral hemorrhage can therefore raise suspicion of an occult CM as a likely cause, a clue which may be invaluable for daily clinical practice. The main focus of this review is to acknowledge the hallmark imaging appearances of DVAs and CMs, as well as their coexistence, explore the clinical consequences of mixed lesions, and emphasize that recognizing their partnership is vital for an accurate, timely diagnosis and appropriately targeted management.

World Journal of RadiologyVol. 17(12)
National and Kapodistrian University of Athens (GR), St Savas Hospital (GR), University General Hospital Attikon (GR), Moorfields Eye Hospital (GB), Sotiria General Hospital (GR), University College London (GB)
Partnerships for the goals
Openalex Percentile: Top 31%
Vascular Malformations Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Developmental venous anomalies and cerebral cavernous malformations: Partners in crime — Evgenia Efthymiou, Olympia Papakonstantinou, et al. · World Journal of Radiology (2025) | TGRS Research Map | TGRS