A novel metric of self and informant reported cognitive complaints in subjective cognitive decline and mild cognitive impairment

Using a novel method of quantifying SCCs reported during clinical interview, we found informant concerns regarding memory, orientation, and navigation differentiated between SCD and MCI. Self-reported SCCs reflected depressive symptoms and broad cognitive concerns, but nonetheless also correlated with objective performance. Informant-based SCCs may have more utility for diagnosis, but self-report SCCs can reflect objective performance. A combination of approaches to quantifying SCCs clinically may better characterize cognitive decline in older adults.