Unambiguous analytical separation and improved syntheses of [11C]acetate and [11C]acetoacetate
Reliable synthesis protocols for [<sup>11</sup>C]acetate and [<sup>11</sup>C]acetoacetate were established on the GE TRACERlab FX2 C, with significant improvements in [<sup>11</sup>C]CO<sub>2</sub> handling and product purification. Inclusion of the proposed RP-HPLC method enables a more accurate and specific assessment of RCP compared to IEX-HPLC alone and should be considered for a valid quality control of [<sup>11</sup>C]acetoacetate.
Authors
- Karsten Bamminger (ORCID: https://orcid.org/0000-0003-3811-7485)
- Marius Ozenil (ORCID: https://orcid.org/0000-0001-6369-6613)
- Lukas Nics (ORCID: https://orcid.org/0000-0002-1034-876X)
- Cécile Philippe
- Marcus Hacker
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s41181-025-00412-0
- Citations
- 1
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.81