Visual short‐term memory binding, locus coeruleus integrity, and subjective cognitive decline in cognitively unimpaired older adults
Subtle losses in cognitive efficiency detected in cognitively unimpaired older adults on a VSTMB task were associated with SCD and LC integrity, even after accounting for performance on traditional neuropsychological tests. Given its role in modulating cortical efficiency through cognitive effort, reduced LC integrity may be associated with SCD when capacity for increasing compensatory effort to perform tasks is exceeded.
Authors
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Amy J. Jak (ORCID: https://orcid.org/0000-0001-8588-1430)
- Eric Granholm (ORCID: https://orcid.org/0000-0003-2040-7951)
- Nathan Whitsel (ORCID: https://orcid.org/0000-0003-2413-4903)
- Rosemary Toomey (ORCID: https://orcid.org/0000-0001-5981-6934)
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Chandra A Reynolds
- for the Vietnam Era Twin Study of Aging
- Matthew S. Panizzon
- Anders M. Dale
- Diane M. Jacobs
- William S. Kremen
Institutions
- University of Colorado Boulder (US)
- University of California San Diego (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107146
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00